Synonym: [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2- [[(2,2-dimethylcyclopropyl)carbonyl]amino]-2- heptenoic acid monosodium salt
Application: A dipeptidase inhibitor with nephroprotective effects
CAS Number: 81129-83-1
Molecular Weight: 380.44
Molecular Formula: C16H25N2O5S•Na
Solubility: Soluble in water (25 mg/mL), DMSO (10 mg/mL), and methanol.
Storage: Store at -20° C
Cilastatin sodium is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.